HER2/neu-specific antibodies and methods of using the same
US9243069B2 · kind B2 · utility
11Cited by
60References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 15, 2014 |
| Grant date | Jan 26, 2016 |
| Priority date | — |
| Expiry date | Jul 15, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to antibodies that specifically bind HER2/neu, and particularly chimeric 4D5 antibodies to HER2/neu, which have reduced glycosylation as compared to known 4D5 antibodies. The invention also relates to methods of using the 4D5 antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.