Compositions and methods for generating an immune response

US9254319B2 · kind B2 · utility

Assignees

• EMORY UNIVERSITY · US
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Harriet Robinson · Atlanta, US
• James Smith · Forfar, GB
• Rama Rao Amara · Atlanta, US
• Bernard Moss · Bethesda, US
• Salvatore T. Butera · Stockbridge, US
• Dennis Ellenberger · Norcross, US

Key dates

• Filing date: Dec 20, 2013
• Grant date: Feb 9, 2016
• Expiry date: Dec 20, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/60
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

We have developed DNA and viral vectors that can be used, alone or in combination, as a vaccine against one HIV clade, subtype, or recombinant form of HIV or against multiple HIV clades, subtypes, or recombinant forms. Moreover, the vectors can encode a variety of antigens, which may be obtained from one clade or from two or more different clades, and the antigens selected and/or the manner in which the vectors are formulated (e.g., mixed) can be manipulated to generate a protective immune response against a variety of clades (e.g., the clades to which a patient is most likely to be exposed; with the proportions of the components of the vaccine tailored to the extent of the patient's risk to a particular clade or clades).