Substituted imidazopyridazines

US9255100B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Ulrich Klar · Berlin, DE
• Marcus Koppitz · Berlin, DE
• Rolf Jautelat · Haan, DE
• Dirk Kosemund · Berlin, DE
• Rolf Bohlmann · Berlin, DE
• Philip Lienau · Berlin, DE
• Gerhard Siemeister · Berlin, DE
• Antje Margret Wengner · Berlin, DE

Key dates

• Filing date: Sep 6, 2011
• Grant date: Feb 9, 2016
• Expiry date: Sep 6, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted imidazopyridazine compounds of general formula (I), which are Mps-1 (Monopolar Spindle 1) Kinase inhibitors (also known as Tyrosine Threonine Kinase, TTK) in which R3, R5, and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.