Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators

US9255110B2 · kind B2 · utility

Assignees

• Roche Palo Alto LLC · US
• Hoffmann-La Roche Inc. · US

Inventors

• Nidhi Arora · Cupertino, US
• Shaoqing Chen · Bound Brook, US
• Johannes Cornelius Hermann · Jersey City, US
• Andreas Kuglstatter · Soest, DE
• Sharada Labadie · Sunnyvale, US
• Clara Jeou Jen Lin · Palo Alto, US
• Matthew C. Lucas · Sunnyvale, US
• Amy Geraldine Moore · Mountain View, US
• Eva Papp · Palo Alto, US
• Francisco Xavier Talamas · Livingston, US
• Jutta Wanner · Palm Beach, US
• Yansheng Zhai · East Palo Alto, US

Key dates

• Filing date: Apr 2, 2014
• Grant date: Feb 9, 2016
• Expiry date: Apr 2, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I or II:wherein X, m, Ar, R1 and R2 are as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.