Pyrazolo[3,4-c]pyridine compounds and methods of use

US9260425B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Steven Do · San Jose, US
• Huiyong Hu · Fremont, US
• Aleksandr Kolesnikov · Mill Valley, US
• Wendy Lee · Hamden, US
• Vickie Hsiao-Wei Tsui · Burlingame, US
• Xiaojing Wang · Foster City, US
• Zhaoyang Wen · South San Francisco, US

Key dates

• Filing date: Aug 10, 2012
• Grant date: Feb 16, 2016
• Expiry date: Aug 10, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pyrazolo[3,4-c]pyridine compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.