Method of synthesizing thyroid hormone analogs and polymorphs thereof
US9266861B2 · kind B2 · utility
7Cited by
4References
17Claims
0Family size
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Key dates
| Filing date | Mar 17, 2015 |
| Grant date | Feb 23, 2016 |
| Priority date | — |
| Expiry date | Mar 17, 2035 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRβ mutation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.