Patent · US Active

Amino acid sequence presenting fusion polypeptide and its use

US9266962B2 · kind B2 · utility

2Cited by

0References

1Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Herbert Andres · Penzberg, DE
David Casagolda Vallribera · Penzberg, DE
Hartmut Duefel · Schlehdorf, DE
Michael Gerg · Munich, DE
Christian Scholz · Penzberg, DE
Michael Schraeml · Penzberg, DE

Key dates

Filing date	May 4, 2012
Grant date	Feb 23, 2016
Priority date	—
Expiry date	May 4, 2032

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/99
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Herein is reported a fusion polypeptide according to formula (I): NH2—S2—X1—S1—COOH, wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.