Method of treating HCV infection with a small molecule CHK2 inhibitor

US9278089B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• David Waugh · Walkersville, US
• Christopher Self · West Caldwell, US
• Guangtao Zhang · Princeton, US
• Yves Pommier · Bethesda, US
• Robert H. Shoemaker · Royal Oak, US
• Michael Currens · Frederick, US
• John H. Cardellina, II · Fort Detrick, US
• Andrew Jobson · Coventry, GB
• George Lountos · Frederick, US
• Dominic Scudiero · Frederick, US

Key dates

• Filing date: Oct 26, 2012
• Grant date: Mar 8, 2016
• Expiry date: Oct 26, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/96
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of treating an Hepatitis C Virus infection in a patient, comprising providing a therapeutically effective amount, to a patient in need thereof, of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: G1 is a group of the formula or where n is 0, 1, 2, 3, or 4 and Het is a 5- or 6-membered heteroaryl group containing 1 to 4 heteroatoms independently chosen from N, O, and S, which Het is optionally substituted.