Aldosterone synthase inhibitors

US9278093B2 · kind B2 · utility

Assignees

• Merck Sharp & Dohme LLC · US
• ElexoPharm GmbH · DE

Inventors

• Amjad Ali · Freehold, US
• Emmanuel Bey · Enzklösterle, DE
• Rolf Hartmann · Saarburg, DE
• Quingzhong Hu · Riegelsberg, DE
• Lina Yin · Riegelsberg, DE

Key dates

• Filing date: Mar 29, 2013
• Grant date: Mar 8, 2016
• Expiry date: Mar 29, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to tricyclic triazole compounds or their pharmaceutically acceptable salts. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the above-cited compounds or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.