Substituted nucleotide analogs

US9278990B2 · kind B2 · utility

Assignee

• ALIOS BIOPHARMA, INC. · US

Inventors

• David Bernard Smith · San Mateo, US
• Jerome Deval · Pacifica, US
• Natalia Dyatkina · Mountain View, US
• Leonid Beigelman · San Mateo, US
• Guangyi Wang · Carlsbad, US

Key dates

• Filing date: Oct 21, 2014
• Grant date: Mar 8, 2016
• Expiry date: Oct 21, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs and thiohosphates (including α-thiomonophosphates, α-thiodiphosphates, and α-thiotriphosphates), methods of synthesizing phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs and thiophosphates, and methods of treating viral infections such as HCV, with the phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs and thiophosphates.