Compounds and methods for treating inflammatory and fibrotic disorders
US9290450B2 · kind B2 · utility
5Cited by
58References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 28, 2014 |
| Grant date | Mar 22, 2016 |
| Priority date | — |
| Expiry date | Apr 28, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.