Activators of human pyruvate kinase

US9290512B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Craig J. Thomas · Gaithersburg, US
• Douglas S. Auld · Waltham, US
• James Inglese
• Amanda P. Skoumbourdis · Langhorne, US
• Jian-Kang Jiang · Columbia, US
• Matthew B. Boxer · Point of Rocks, US

Key dates

• Filing date: Dec 19, 2014
• Grant date: Mar 22, 2016
• Expiry date: Dec 19, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are pyruvate kinase M2 activators, which are, bis sulfonamide piperazinyl compounds of Formula (I) and 2,4-disubstituted 4H-thieno[3,2-b]pyrrole-2-(substituted benzyl)pyridazin-3(2H)ones of Formula (II), wherein L and R1 to R16 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia, Formulas (I); (II).