Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists

US9296729B2 · kind B2 · utility

Assignees

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US
• Forschungsverbund Berlin e.V. · DE

Inventors

• Marvin C. Gershengorn · Washington, US
• Susanne Neumann · Speyer, DE
• Bruce M. Raaka · Rockville, US
• Craig J. Thomas · Gaithersburg, US
• James Inglese
• Noel Terrence Southall · Bethesda, US
• Steven Titus · Elkridge, US
• Wenwei Huang · Rockville, US
• Gerd Krause · Berlin, DE
• Gunnar Kleinau · Berlin, DE
• Wei Zheng · Rockville, US

Key dates

• Filing date: Apr 2, 2014
• Grant date: Mar 29, 2016
• Expiry date: Apr 2, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.