Antibodies with enhanced or suppressed effector function
US9296815B2 · kind B2 · utility
5Cited by
10References
14Claims
0Family size
Assignee
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Key dates
| Filing date | Mar 28, 2011 |
| Grant date | Mar 29, 2016 |
| Priority date | — |
| Expiry date | Aug 13, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.