Processes for the preparation of (S)-3-(4- (4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable forms thereof

US9309220B2 · kind B2 · utility

Assignee

• CELGENE CORPORATION · US

Inventors

• John F. Traverse · Lebanon, US
• Chengmin Zhang · Florham Park, US
• Gregg Feigelson · Monsey, US
• Benjamin M. Cohen · Cranford, US
• William W. Leong · Westfield, US

Key dates

• Filing date: Aug 8, 2013
• Grant date: Apr 12, 2016
• Expiry date: Oct 2, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are processes for the preparation of enantiomerically enriched or enantiomerically pure 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a pharmaceutically acceptable form thereof.