Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof

US9315471B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Srinivasan Babu · San Diego, US
• Francis Gosselin · South San Francisco, US
• Yingqing Ran · South San Francisco, US
• Travis Remarchuk · South San Francisco, US
• Scott Savage · Redwood City, US
• Jeffrey S. Stults · Grand Island, US
• Herbert Yajima · San Francisco, US

Key dates

• Filing date: May 17, 2013
• Grant date: Apr 19, 2016
• Expiry date: May 17, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides new processes for making and purifying salts of hydroxylated cyclopentapyrimidine compounds, which are useful as AKT inhibitors used in the treatment of diseases such as cancer, including the monohydrochloride salt of (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.