Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
US9328106B2 · kind B2 · utility
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23Claims
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Key dates
| Filing date | Sep 25, 2013 |
| Grant date | May 3, 2016 |
| Priority date | — |
| Expiry date | Feb 15, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R2 is a cyclic ether and X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.