Lipopeptide inhibitors of RAS oncoproteins

US9328142B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• Joseph Robert Kates · US
• Yin Hwee Tan · CA
• VANDERBILT UNIVERSITY · US
• The Board of Trustees of the University of Illinois · US

Inventors

• Nadya I. Tarasova · Frederick, US
• Sergey G. Tarasov · Frederick, US
• Vadim Gaponenko · Naperville, US
• Joseph Kates · Kirkland, US
• Alla Ivanova · Madison, US
• Michael Dean · Frederick, US

Key dates

• Filing date: May 25, 2012
• Grant date: May 3, 2016
• Expiry date: May 25, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/82
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a peptide or peptidomimetic that is derived from or based upon the amino acid sequence of the C-terminal α-helix or hypervariable region (HVR) or a Ras protein, a nucleic acid encoding the peptide or peptidomimetic, and methods employing the same.