Cyclic amine substituted heterocyclic CETP inhibitors

US9353101B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• John J. Acton, III · Cranford, US
• Feng Ye · Scotch Plains, US
• Petr Vachal · Summit, US
• Deyou Sha · Yardley, US
• James F. Dropinski · Colts Neck Township, US
• Lin Chu · Scotch Plains, US
• Debra L. Ondeyka · Fanwood, US
• Alexander Kim · Levittown, US
• Vincent J. Colandrea · New Brunswick, US
• Yi Zang · Princeton Junction, US
• Fengqi Zhang · Gaorihan, CN
• Guizhen Dong

Key dates

• Filing date: Apr 26, 2013
• Grant date: May 31, 2016
• Expiry date: Apr 26, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising HDL-cholesterol and reducing LDL-cholesterol in human patients and for treating or preventing atherosclerosis.