Process for making modulators of cystic fibrosis transmembrane conductance regulator

US9371287B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• John DeMattei · San Diego, US
• Adam Looker · Newton, US
• Bobbianna Neubert-Langille · Sudbury, US
• Martin Trudeau · Shannon, US
• Stefanie Roeper · Medford, US
• Michael P. Ryan · Brookline, US
• Dahrika Milfred Yap Guerette · Cambridge, US
• Brian R. Krueger · Cambridge, US
• Peter Diederik Jan Grootenhuis · San Diego, US
• Fredrick Van Goor · San Diego, US
• Martyn Botfield · Concord, US
• Gregor Zlokarnik · Village of La Jolla, US

Key dates

• Filing date: May 23, 2014
• Grant date: Jun 21, 2016
• Expiry date: May 23, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a process for the preparation of a compound of Formula 1,comprising coupling a carboxylic acid of Formula 2with an aniline of Formula 3in the presence of a coupling agent.