Deimmunized serum-binding domains and their use in extending serum half-life
US9376495B2 · kind B2 · utility
10Cited by
51References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 16, 2012 |
| Grant date | Jun 28, 2016 |
| Priority date | — |
| Expiry date | Jun 27, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/73
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is directed to a polypeptide (for example, an antigen-binding molecule) that comprises a polypeptide portion of a deimmunized serum-binding protein capable of binding to said serum protein. The presence of the serum-binding protein extends the serum half-life of the polypeptide, relative to the serum half-life of the polypeptide if lacking the polypeptide portion of the deimmunized serum-binding protein. The invention also pertains to methods and uses that employ such molecules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.