Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof therapeutic uses thereof
US9387243B2 · kind B2 · utility
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3References
33Claims
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Key dates
| Filing date | Dec 16, 2013 |
| Grant date | Jul 12, 2016 |
| Priority date | — |
| Expiry date | Dec 16, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/20022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains the property of said adenylate cyclase protein to target Antigen Presenting Cells. It also concerns polynucleotides encoding the same. The recombinant protein or the polynucleotide can be used for the design of therapeutic means against HPV infection or against its malignant effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.