N-substituted indazole sulfonamide compounds with selective activity in voltage-gated sodium channels

US9388179B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Joseph E. Pero · Harleysville, US
• Hannah D. G. F. Lehman · Boyertown, US
• Mark E. Layton · Harleysville, US
• Michael A. Rossi · Limerick, US
• Michael J. Kelly, III · Paoli, US

Key dates

• Filing date: Oct 23, 2013
• Grant date: Jul 12, 2016
• Expiry date: Oct 23, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula AA and Formula AB: wherein “Heteroaryl-1”, RA1, RA2, RB1, and RC are defined herein, which novel compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formulae AA and AB or their salts, and methods of treating neuropathic pain disorders using the same.