Multivalent heteromultimer scaffold design and constructs
US9388231B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 13, 2013 |
| Grant date | Jul 12, 2016 |
| Priority date | — |
| Expiry date | Jul 13, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/31
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein are multifunctional heteromultimer proteins. In specific embodiments is a heteromultimer comprising: at least two polypeptide constructs, each polypeptide construct comprising at least one cargo polypeptide attached to a transporter polypeptide, said transporter polypeptides derived from a monomeric native protein such that said monomeric constructs associate to form the heteromultimer and said transporter polypeptides associate to form a quasi-native structure of the monomeric native protein or analog thereof. These therapeutically novel molecules encompass heteromultimers comprising constructs that function as scaffolds for the conjugation or fusion of therapeutic molecular entities (cargo polypeptides) resulting in the creation of bispecific or multivalent molecular species. Provided herein is a method for creation of bispecific or multivalent molecular species.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.