Inhibitors of influenza viruses replication

US9394302B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Paul S. Charifson · Framingham, US
• Michael P. Clark · Maineville, US
• Upul K. Bandarage · Lexington, US
• Randy S. Bethiel · Bedford, US
• Michael Boyd · Winchester, US
• Ioana Davies · Arlington, US
• Hongbo Deng · Southborough, US
• John P. Duffy · Westborough, US
• Luc Farmer · Foxborough, US
• Huai Gao · Arlington, US
• Wenxin Gu · Concord, US
• Joseph M. Kennedy · Walpole, US
• Brian Ledford · Attleboro, US
• Mark Ledeboer · Acton, US
• Francois Maltais · Somerville, US
• Emanuele Perola · Cambridge, US
• Tiansheng Wang · Concord, US

Key dates

• Filing date: Mar 24, 2015
• Grant date: Jul 19, 2016
• Expiry date: Mar 24, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides methods of preparing 3-(pyrimidin-2-yl)-1H-pyrrolo[2,3-b]pyridines and 3-(pyrimidin-2-yl)-1H-pyrazolo[3,4-b]pyridines, or pharmaceutically acceptable salts thereof that are useful for inhibiting the replication of influenza viruses in a biological sample or patient, reducing the amount of influenza viruses in a biological sample or patient, and treating influenza in a patient.