Patent · US Active

Method for improving the stability of purified factor VIII after reconstitution

US9394353B2 · kind B2 · utility

3Cited by

10References

7Claims

0Family size

Assignee

CSL LIMITED · AU

Inventors

Carsten Horn · Ettenheim, DE
Sabine Zollner · Muri, CH
Hubert Metzner · Marburg, DE
Stefan Schulte · Marburg, DE

Key dates

Filing date	Oct 18, 2012
Grant date	Jul 19, 2016
Priority date	—
Expiry date	Oct 18, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K14/755
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a method for increasing the stability of a Factor VIII molecule after purification, lyophilization and reconstitution, comprising preventing proteolytic cleavage of the Factor VIII molecule into a first fragment comprising essentially the A1 domain and the A2 domain and a second fragment comprising essentially the A3 domain, the C1 domain and the C2 domain throughout manufacturing of the Factor VIII molecule. The invention further pertains to a method for improving the bioavailability of Factor VIII after intravenous and non-intravenous injection.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.