Benzofuran-containing amino acid inhibitors of cytochrome P450
US9403789B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 23, 2009 |
| Grant date | Aug 2, 2016 |
| Priority date | — |
| Expiry date | Jun 17, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Benzofuran-containing amino acid compounds are provided that are potent inhibitors of cytochrome P450 (CYP) enzymes. The compounds have the general structurewhere at least one of R1, R2, R3, R4, R5, and R6 is —S(O)n—(CH2)0-3-(benzofuranyl), —(CH2)1-5—N(R)(—SO2-benzofuranyl), —C(O)n—(CH2)0-3-(benzofuranyl), —(CH2)1-5—N(R)(C(═O)-(benzofuranyl), or C1-C6 alkylene-(benzofuranyl). Pharmaceutical compositions containing the inhibitors are provided and these compositions can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.