Fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives and methods of use thereof

US9422263B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Martin Michels
• Markus Follmann
• Alexandros Vakalopoulos · Hilden, DE
• Katja Zimmermann · Mülheim an der Ruhr, DE
• Nicole Teusch · Uerdingen, DE
• Mario Lobell · Wuppertal, DE
• Donald Bierer · Daly City, US
• Karen Engel · Waldkraiburg, DE
• Maria Kissel · Wuppertal, DE

Key dates

• Filing date: Oct 1, 2010
• Grant date: Aug 23, 2016
• Expiry date: Dec 7, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.