Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use

US9434735B2 · kind B2 · utility

Assignee

• Signal Pharmaceuticals, LLC · US

Inventors

• Ming J. Chen · Valley Cottage, US
• Jale Muslehiddinoglu · Beerse, BE
• Alexander L. Ruchelman · Cream Ridge, US
• Terrence Joseph Connolly · Rocky Hill, US

Key dates

• Filing date: Jul 13, 2015
• Grant date: Sep 6, 2016
• Expiry date: Jul 13, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein is an amorphous form of 4-((4-(Cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide, compositions thereof, and methods of their use for treating or preventing a cancer, in particular solid tumors and hematological cancers as described herein.