Patent · US Active

Methods and compositions for gene inactivation

US9434776B2 · kind B2 · utility

22Cited by

33References

23Claims

0Family size

Assignee

Sangamo Biosciences, Inc. · US

Inventors

Dale Ando · Richmond, US
Michael C. Holmes · Richmond, US
Gary K. Lee · San Leandro, US

Key dates

Filing date	Oct 15, 2013
Grant date	Sep 6, 2016
Priority date	—
Expiry date	Oct 15, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2710/10345
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.