Process for the preparation of pralatrexate

US9440979B2 · kind B2 · utility

Assignee

• Fresenius Kabi Oncology Ltd. · IN

Inventors

• Saswata Lahiri · Sindhar, IN
• Nitin Gupta · Savanuru, IN
• Hemant Kumar Singh · Lucknow, IN
• Nilendu Panda · Barwala, IN
• Vishal Handa · Barwala, IN
• Azim Abul · Manesar, IN
• Chandan Gupta · Dhamtari, IN
• Sunil Sanghani · Manesar, IN
• Ghanashyam Madhukar Sonavane · Barwala, IN

Key dates

• Filing date: Jul 18, 2013
• Grant date: Sep 13, 2016
• Expiry date: Jul 18, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C67/343
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An improved process for the preparation of Pralatrexate which is less hazardous. The invention further relates to novel intermediates and process thereof useful for the preparation of Pralatrexate. The present invention also relates to a substantially pure Pralatrexate and a process for obtaining the same in high yield.