6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

US9447086B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Lei Guo · Kowloon, CN
• Taishan Hu · Shanghai, CN
• Yimin Hu · Shanghai, CN
• Buelent Kocer · Basel, CH
• Xianfeng Lin · Shanghai, CN
• Haixia Liu · Shanghai, CN
• Alexander V. Mayweg · Basel, CH
• Zongxing Qiu · Shanghai, CN
• Hong Shen · Shanghai, CN
• Guozhi Tang · Shanghai, CN
• Lisha Wang · Basel, CH
• Guolong Wu · Shanghai, CN
• Shixiang Yan · Shanghai, CN
• Weixing Zhang · Shanghai, CN
• Mingwei Zhou · Shanghai, CN
• Wei Zhu · Shanghai, CN

Key dates

• Filing date: Sep 10, 2013
• Grant date: Sep 20, 2016
• Expiry date: Sep 10, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides novel compounds having the general formula:wherein R1, R2, R3, R4 and A are as described herein, compositions including the compounds and methods of using the compounds.