Regulation of specific spinal neurons regulating pain transmission via chimeric toxins
US9447405B2 · kind B2 · utility
4Cited by
3References
4Claims
0Family size
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Key dates
| Filing date | Feb 14, 2014 |
| Grant date | Sep 20, 2016 |
| Priority date | — |
| Expiry date | May 8, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain, wherein the ligand is linked to the light chain. The methods of preparing such chimeric toxin and the method of using the chimeric toxin to regulate pain transmission are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.