2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases

US9457039B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Vinay M. Girijavallabhan · Woburn, US
• Stephane L. Bogen · Somerville, US
• Weidong Pan · Somerville, US
• Qun Dang · Westfield, US
• Ian Davies · Princeton, US

Key dates

• Filing date: Oct 11, 2013
• Grant date: Oct 4, 2016
• Expiry date: Oct 11, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H7/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

2′-disubstituted substituted nucleoside derivatives of formula (I) and pharmaceutically acceptable salts thereof are disclosed: (1), wherein A is N3 or NH2 and X, Y, R1, R2, R3, R4, R5 and R18 are as defined herein. Compositions comprising at least one 2′-disubstituted nucleoside derivative, and methods of using the 2′-disubstituted nucleoside derivatives for treating or preventing HCV infection in a patient are disclosed.