Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (PD-1) pathway

US9457080B2 · kind B2 · utility

Assignees

• EMORY UNIVERSITY · US
• DANA-FARBER CANCER INSTITUTE, INC. · US
• The Brigham and Women's Hospital, Inc. · US
• President and Fellows of Harvard College · US

Inventors

• Gordon J. Freeman · Brookline, US
• Arlene H. Sharpe · Brookline, US
• David M. Dorfman · Brookline, US
• Rafi Ahmed · Fremont, US
• Daniel Barber · Rockville, US
• E. John Wherry · Havertown, US

Key dates

• Filing date: Dec 30, 2013
• Grant date: Oct 4, 2016
• Expiry date: May 11, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer.