Carboxamide or sulfonamide substituted nitrogen-containing 5-membered heterocycles as modulators for the orphan nuclear receptor RORγ

US9458104B2 · kind B2 · utility

Assignee

• PHENEX PHARMACEUTICALS AG · DE

Inventors

• Christian Gege · Ehingen (Donau), DE
• Olaf Kinzel · Heidelberg, DE
• Christoph Steeneck · Dossenheim, DE
• Gerald Kleymann · Bad Salzuflen, DE
• Thomas Hoffmann · Santa Cruz, US

Key dates

• Filing date: May 29, 2013
• Grant date: Oct 4, 2016
• Expiry date: May 29, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide containing cyclic compounds of Formula (1) to Formula (5) and the enantiomers, diastereomers, tautomers, /V-oxides, solvates and pharmaceutically acceptable salts thereof.