Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity

US9458113B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Stefan Peters · Biberach an der Riß, DE
• Ralf Anderskewitz · Laupheim, DE
• Christian Gnamm · Biberach an der Riß, DE
• Holger Hoesch · Biberach an der Riß, DE
• Gerd Morschhaeuser · Biberach, DE
• Thorsten Oost · Biberach an der Riß, DE
• Uwe Ries · Biberach an der Riß, DE

Key dates

• Filing date: Jul 27, 2015
• Grant date: Oct 4, 2016
• Expiry date: Jul 27, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted dihydropyrimidinones of formula 1which are neutrophil elastase inhibitors and useful as medicaments for the treatment of, inter alia, COPD. Exemplary is