Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists

US9458141B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• Forschungsverbund Berlin e.V. · DE

Inventors

• Marvin C. Gershengorn · Washington, US
• Susanne Neumann · Speyer, DE
• Bruce M. Raaka · Rockville, US
• Craig J. Thomas · Gaithersburg, US
• James Inglese
• Noel Terrence Southall · Bethesda, US
• Steven Titus · Elkridge, US
• Wei Zheng · Rockville, US
• Wenwei Huang · Rockville, US
• Gerd Krause · Berlin, DE
• Gunnar Kleinau · Berlin, DE

Key dates

• Filing date: Sep 29, 2015
• Grant date: Oct 4, 2016
• Expiry date: Sep 29, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.