Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs
US9469868B2 · kind B2 · utility
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31References
17Claims
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Key dates
| Filing date | Nov 4, 2009 |
| Grant date | Oct 18, 2016 |
| Priority date | — |
| Expiry date | Nov 3, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/582
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods and compositions which can be used to increase the strength and/or probability of forming a binding complex comprising a target molecule and a substrate are disclosed. In one aspect, linking molecules having one or more members of a reactive pair are disclosed which can be used to increase the number of intra-complex binding interactions in a complex comprising a target molecule and a substrate. Intra-complex crosslinking and inter-complex crosslinking can be utilized in connection with these methods and compositions to further strengthen and stabilize the disclosed binding complexes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.