Vaccines and methods for prevention and treatment of drug-resistant HIV-1 and hepatitis B virus
US9474793B2 · kind B2 · utility
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4Claims
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Key dates
| Filing date | Feb 22, 2006 |
| Grant date | Oct 25, 2016 |
| Priority date | — |
| Expiry date | Jul 15, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/24222
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods for lowering a viral load of a virus resistant to an antiviral drug by inducing cytotoxic T lymphocytes (CTL) to recognize a predetermined mutated epitope within a viral protein of the drug-resistant virus. CTLs are induced by immunizing a host with a peptide comprising the predetermined mutation. The immunostimulating peptide may be further improved by epitope-enhancement for inducing specific CTLs. The antiviral protection against drug-resistant virus shown by compositions of the present invention and mediated by human HLA-restricted CTL has not been previously achieved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.