Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
US9492553B2 · kind B2 · utility
8Cited by
12References
4Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 16, 2014 |
| Grant date | Nov 15, 2016 |
| Priority date | — |
| Expiry date | Apr 16, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to antibody-drug conjugate compounds of Formula I:Ab-(L-D)p Iwhere one or more nemorubicin metabolite or analog drug moieties (D) are covalently attached by a linker (L) to an antibody (Ab) which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be useful in methods of diagnosis or treatment of cancer, and other diseases and disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.