Inhibitors of the renal outer medullary potassium channel

US9493474B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Shawn P. Walsh · Bound Brook, US
• Alexander Pasternak · Brookline, US
• Zhi-Cai Shi · Monmouth Junction, US
• Brian Cato · Secaucus, US
• Esther Y. Kim · Cheltenham, US

Key dates

• Filing date: Oct 25, 2012
• Grant date: Nov 15, 2016
• Expiry date: Aug 9, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to compounds of Formula I having the following general structure:Z1—Y1—(CH2)n1—R—(CH2)n2—Y2—Z2 wherein R represents a fused bicyclic or spirocyclic aliphatic diamine and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.