Antiproliferative compounds and methods of use thereof

US9499514B2 · kind B2 · utility

Assignee

• CELGENE CORPORATION · US

Inventors

• Joshua Hansen · Village of La Jolla, US
• Matthew D. Correa · San Diego, US
• Raj K. Raheja · Poway, US
• Antonia Lopez-Girona · San Diego, US
• Hon-Wah Man · Princeton, US
• George W. Muller · Northbrook, US
• Ehab M. Khalil · Yorktown, US
• Kyle MacBeth · Boston, US
• Brian E. Cathers · San Diego, US
• Michael Pourdehnad · San Francisco, US

Key dates

• Filing date: Jul 9, 2015
• Grant date: Nov 22, 2016
• Expiry date: Jul 9, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.