Multivalent heteromultimer scaffold design and constructs
US9499605B2 · kind B2 · utility
15Cited by
50References
24Claims
0Family size
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Key dates
| Filing date | Mar 2, 2012 |
| Grant date | Nov 22, 2016 |
| Priority date | — |
| Expiry date | Mar 2, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/31
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein each monomeric protein comprises at least one cargo polypeptide, attached to a transporter polypeptide, such that said monomeric proteins associate to form the heteromultimer. These therapeutically novel molecules comprise monomers that function as scaffolds for the conjugation or fusion of therapeutic molecular entities resulting in the creation of bispecific or multivalent molecular species.
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