Tetracyclic xanthene derivatives and methods of use thereof for the treatment of viral diseases

US9504690B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Craig A. Coburn · Royersford, US
• Stuart B. Rosenblum · West Orange, US
• Joseph A. Kozlowski · Princeton, US
• Richard Soll · San Diego, US
• Hao Wu · Shanghai, CN
• Bin Hu · Mesa, US
• Bin Zhong · Shanghai, CN
• Dahai Wang · Shanghai, CN
• Changmao Shen · Shanghai, CN
• Fei Sun · Shanghai, CN

Key dates

• Filing date: Mar 16, 2012
• Grant date: Nov 29, 2016
• Expiry date: Jun 23, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel Tetracyclic Xanthene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, Y1, Y2, Z, Ra, Rb, R1a, R1b and R2 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Xanthene Derivative, and methods of using the Tetracyclic Xanthene Derivatives for treating or preventing HCV infection in a patient.