Steroid compounds as RORyt modulators and uses thereof

US9505798B2 · kind B2 · utility

Assignees

• NEW YORK UNIVERSITY · US
• Memorial Sloan Kettering Cancer Center · US

Inventors

• Dan R. Littman · New York, US
• Jun R. Huh · Newton, US
• Nicolas Manel · Montpellier, FR
• Daniel A. Ryan · San Diego, US
• David Y. Gin · New York, US
• Michael R. Krout · La Cañada Flintridge, US

Key dates

• Filing date: Nov 28, 2011
• Grant date: Nov 29, 2016
• Expiry date: May 26, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J19/005
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Steroid compounds are disclosed that have a formula represented by the following:and wherein m, n, t, u1, u2, v1, v2, R1a, R1b, R2a, R2b, R3a, R3b, R3c, R3d, and Y are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the treatment or prevention of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.