Indazole compounds as aldosterone synthase inhibitors

US9522141B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Scott B. Hoyt · Hoboken, US
• Jerry Andrew Taylor · Trenton, US
• Clare London · Chatham, US
• Yusheng Xiong · Newtown, US
• Andrew Cooke · Doylestown, US

Key dates

• Filing date: Dec 17, 2013
• Grant date: Dec 20, 2016
• Expiry date: Dec 17, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to indazole compounds of the structural formula: (structure represented) or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment or amelioration of conditions that could be treated by inhibiting aldosterone synthase.