Thieno-indole moieties and methods of treating using the same
US9527863B2 · kind B2 · utility
3Cited by
0References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 28, 2013 |
| Grant date | Dec 27, 2016 |
| Priority date | — |
| Expiry date | Mar 28, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0804
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a novel class of alkylating agents comprising a thieno-indole moiety linked to a DNA-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them. The invention also relates to the use of this novel class of alkylating agents in the preparation of conjugates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.