Peptide-based stat inhibitor

US9540427B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Nadya I. Tarasova · Frederick, US
• Olga Timofeeva · Rockville, US
• Vadim Gaponenko · Naperville, US
• Christopher J. Michejda · North Potomac, US
• Alan O. Perantoni · Fairfield, US
• Sergey G. Tarasov · Frederick, US

Key dates

• Filing date: May 30, 2008
• Grant date: Jan 10, 2017
• Expiry date: Sep 25, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A peptide or peptidomimetic comprising the amino acid sequence of the second helix of a STAT protein, or a variant of such sequence, wherein the peptide or peptidomimetic comprises about 40 or fewer amino acids and binds to a STAT protein, as well as a method of inhibiting a STAT protein in a cell, a method of treating or preventing a disease associated with STAT overexpression in a host, and related compounds, compositions, and methods.