Substituted pyrazolo[1,5-a]pyrimidines as Syk inhibitors

US9567348B2 · kind B2 · utility

Assignee

• GILEAD CONNECTICUT, INC. · US

Inventors

• Scott A. Mitchell · East Haven, US
• Kevin S. Currie · North Branford, US
• Peter A. Blomgren · Issaquah, US
• Jeffrey E. Kropf · Branford, US
• Seung H. Lee · Sammamish, US
• Jianjun Xu · Bellevue, US
• Douglas G. Stafford · Niskayuna, US

Key dates

• Filing date: Feb 23, 2015
• Grant date: Feb 14, 2017
• Expiry date: Feb 23, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/9121
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain pyrazolo[1,5-a]pyrimidines:or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.